Functional Genomics and Computational Biology Group

Research Areas

1. The roles and regulatory mechanisms of DNA/RNA methylation during early flower development, as well as the interplay between epigenetic nucleotide modification and transcription factors (mainly ABC factors).

2. Molecular evolutionary biology about the DNA/RNA epigenetic mechanisms.

Principal Investigator (PI)
Hongxing Yang, Ph.D
Tel: 86-21-37792288 ext. 908
Email: hxyang@sibs.ac.cn, yanghx81@gmail.com
Address: Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences / Chenshan Botanical Garden 3888 Chenhua Rd., Songjiang Shanghai 201602 China

Education Background

2003.09 - 2009.06, Department of Physics, Fudan University, Ph.D.
1999.09 - 2003.06, Department of Physics, Anhui University, Bachelor


Experience

2014.08 - : P.I., Associate Professor, Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences / Shanghai Chenshan Botanical Garden 
2012.05 - 2014.07, Postdoctoral research at The College of Medicine, University of Iowa
2009.09 - 2012.05, Postdoctoral researchat School of Life Sciences, Fudan University

Members
Chao Li
Ph.D., Research Assistant 
Tel: 021-37792288 ext. 662
Email: cslichao@ csnbgsh.com
Haiyan Zhuang
Ph.D., Research Assistant 
Tel: 021-37792288 ext. 662
Email: landscape_3761@163.com
Ling Wang
M.S., Research Assistant 
Tel: 021-37792288 ext. 662
Email: wangling@ csnbgsh.com
Xiang Liu
Ph.D., Research Assistant 
Tel: 021-37792288 ext. 915
Email: xiang_liu@hotmail.com

Publications
  1. Shuang-Shuang Zhang , Hongxing Yang , Lan Ding, Ze-Ting Song, Hong Ma, Fang Chang *, and Jian-Xiang Liu *. Tissue-specific transcriptomics reveals important role of the unfolded protein response in maintaining fertility upon heat stress in Arabidopsis. Plant Cell. 2017. 29(5): 1007–1023 

  2. Karina Kruth, Mimi Fang, Dawne N. Shelton, Ossama Abu-Halawa, Ryan Mahling, Hongxing Yang, Jonathan S. Weissman, Mignon L. Loh, Markus Müschen, Sarah, K. Tasian, Michael C. Bassik, Martin Kampmann and Miles A. Pufall. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017. 129(22): 3000-3008 

  3. Yi Tao , Guang Yang , Hongxing Yang , Dongliang Song, Liangning Hu, Bingqian Xie, Houcai Wang, Lu Gao, Minjie Gao, Hongwei Xu, Zhijian Xu, Xiaosong Wu, , Yiwen Zhang, Weiliang Zhu, Fenghuang Zhan, Jumei Shi. TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma. Oncotarget. 2017. 8(16): 26718–26731. 

  4. Jiani Yin, Wu Chen, Hongxing Yang, Mingshan Xue, and Christian Schaaf. Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. Scientific Reports. 2017.7:39941. 

  5. Qin Zhou, Chao Li, Kohei Mishina, Jiecai Zhao, Jiwei Zhang, Ruijun Duan, Xiaoying Ma, Aidong Wang, Qianxiang Meng, Takao Komatsuda, Guoxiong Chen. Characterization and genetic mapping of the β-diketone deficient eceriferum-b barley mutant. Theoretical and Applied Genetics. 2017. 130(6): 1169-1178. 

  6. Chao Li, Guoxiong Chen, Kohei Mishina, Naoki Yamaji, Jian Feng Ma, Fumiko Yukuhiro, Akemi Tagiri, Cheng Liu, Mohammad Pourkheirandish, Nadia Anwar, Masaru Ohta, Pengshan Zhao, Udda Lundqvist, Xinrong Li, Takao Komatsuda. A GDSL-motif esterase/acyltransferase/lipase is responsible for leaf water retention in barley. Plant Direct. 2017. 1(5): e00025.

  7. Hongxing Yang, Fang Chang*, Chenjiang You, Jie Cui, Genfeng Zhu, Lei Wang, Yu Zheng, Ji Qi*, Hong Ma*. Whole-genome DNA methylation patterns and complex function in transcription regulation during flower development in Arabidopsis. Plant Journal. 2015. 81(2): 268-281. (Times cited: 12)

  8. Yue Jin, Hongxing Yang, Zheng Wei, Hong Ma*, Xiaochun Ge*. Rice Male Development under Drought Stress: Phenotypic Changes and Stage-Dependent Transcriptomic Reprogramming. Molecular Plant. 2013. 6(5): 1630-1645. (Times cited: 23)

  9. Hongxing Yang, Pingli Lu, Yingxiang Wang* and Hong Ma*.The transcriptome landscape of Arabidopsis male meiocytes from high-throughput sequencing: the complexity and evolution of the meiotic process. Plant Journal. 2011. 65(4): 503-16. (Times cited: 90)